WebJun 8, 2012 · The autosomal-recessively inherited disorder, Chudley-McCullough Syndrome (CMS [MIM 604213 ]), was first described 1 in Canadian siblings of Dutch-German Mennonite (sometimes referred to as Old Colony or Chortitza Mennonite) ancestry, who presented with hydrocephalus and profound sensorineural hearing loss. WebOct 6, 2024 · The technical storage or access is strictly necessary for the legitimate purpose of enabling the use of a specific service explicitly requested by the subscriber or user, or for the sole purpose of carrying out the transmission of a communication over an electronic communications network.
GPSM2 Mutations Cause the Brain Malformations and …
WebChudley-Mccullough syndrome is a rare genetic disorder which is characterized by bilateral congenital (sometimes progressive) hearing loss associated with brain malformations. It … WebChudley-McCullough syndrome is an autosomal recessive neurologic disorder characterized by early-onset sensorineural deafness and specific brain anomalies on MRI, including hypoplasia of the corpus callosum, enlarged cysterna magna with mild focal cerebellar dysplasia, and nodular heterotopia. Some patients have hydrocephalus. diane burt torrington
Brothers with Chudley–McCullough syndrome: Sensorineural …
WebAbstract Background: Chudley McCullough syndrome is characterized by partial agenesis of the corpus callosum, interhemispheric cyst, cerebral and cerebellar cortical dysplasias, and hydrocephalus. This syndromic form of sensorineural hearing loss is rare. Our literature search has located 13 siblings in 6 families with this syndrome. WebChudley-McCullough syndrome associated with bilateral sen-sorineural deafness and typical brain malformations but with variable clinical prognosis. Patients and Methods We report 2 cases of Chudley-McCullough syndrome with variable neurodevelopmental outcome. Results Patient one is a 14-year-old boy, the first child of a consangui- WebDec 5, 2024 · Chudley-McCullough syndrome is an autosomal recessive neurologic disorder characterized by early-onset sensorineural deafness and specific brain anomalies on MRI, including hypoplasia of the corpus callosum, enlarged cysterna magna with mild focal cerebellar dysplasia, and nodular heterotopia. Some patients have hydrocephalus. diane busby bates