Web301 Moved Permanently. nginx WebCircular RNAs (circRNAs) are highly expressed in the central nervous system and have been reported to be associated with neuropsychiatric diseases, but their potential role in major depressive disorder (MDD) …
Engineering circular RNA for enhanced protein production
WebOct 14, 2024 · To obtain circRNA similarity and disease similarity accurately, MSPCD first integrates more biological information such as circRNA-miRNA associations, circRNA-gene ontology associations, then extracts circRNA and disease high-order features by the neural network. Finally, MSPCD employs DNN to predict unknown circRNA-disease associations. WebApr 7, 2024 · circRNA, which plays a role in biological regulation primarily via gene regulation, is a type of non-coding RNA. circRNAs have extremely abundant binding sites for microRNAs (miRNA) and thus acts via absorption of miRNAs like a sponge [ 15 ]. circRNA can also act on other RNAs by base pairing [ 16 ]. bakery in petaling jaya
Circular RNA: metabolism, functions and interactions with proteins ...
WebApr 2, 2024 · What's more, in the peripheral blood, has-circRNA-103636 can be a potential novel non-invasive biomarker related to diagnosis and therapeutic effects in major depressive disorder (MDD), based on its … WebSep 16, 2024 · Studies showed circRNAs play critical roles in important biological processes through acting as a microRNA (miRNA) sponge, competing endogenous RNA (ceRNA), protein regulator or even by translating themselves to produce peptides and proteins ( 1, 2 ). They are emerging as a novel type of biomarker for human disease ( 1, 2 ). Synthesis of circRNAs via intron-assisted splicing and RNaseR digestion has been previously described4, but rapid creation of different circRNA species was difficult. To enable higher-throughput testing of circRNAs, we created a modular cloning platform consisting of a set of backbones and parts in a clearly … See more We previously showed that circRNAs can trigger immune responses in vivo that can be avoided by modifying circRNAs with m6A4,11. However, the effect of m6A incorporation on circRNA translation is unknown. To … See more 5′ and 3′ UTRs in mRNAs can recruit RNA-binding proteins (RBPs) that enable strong translation as well as aspects of post-transcriptional regulation6. One such family of RBPs is poly(A)-binding proteins (PABPs), which … See more We first sought to uncover principles behind circRNA vector topology that are necessary for strong translation. We began by synthesizing circRNAs with a coxsackievirus B3 (CVB3) IRES (denoted iCVB3) downstream, … See more Viral IRESs are diverse and highly structured RNA regions found primarily in viral 5′ UTRs that promote cap-independent translation30,31,32. Because iCVB3, the baseline IRES used in our study, is nearly 750 … See more arbitration saskatchewan