Cisplatin mouse

WebAntitumor efficacy of aptamer‐siRNA nano‐zinc carriers in a mouse lung cancer model bearing A549/DDP cells. A549/DDP or A549 cells were implanted subcutaneously in nude mice. After 10 days, mice received a single intravenous injection of 5 mg/kg/d A10/NaZ/siUSP14#1 followed by serial fluorescence imaging at the indicated time points. WebAug 17, 2024 · Cisplatin (cis-Diaminodichloroplatinum, CDDP), one of the most potent chemotherapeutic agents, has been proven effective against various solid tumors, including sarcoma, soft tissue cancer, bone cancer, muscle cancer, and vascular cancer.

Chronic effects of repeated low-dose cisplatin treatment in mouse ...

WebOct 1, 2024 · Cisplatin is a potent chemotherapeutic used for the treatment of many types of cancer. However, its dose-limiting side effect is nephrotoxicity leading to acute kidney … WebCisplatin, a chemotherapy drug, is best known for curing testicular cancer. It is also used in the treatment of a wide range of other cancers, including lung, bladder, cervical, and ovarian cancers. Cisplatin and other similar … canned nuts shelf life https://deadmold.com

Examples of mouse cisplatin toxicity protocols used in studies...

WebCisplatin (NSC 119875, Cisplatinum, cis-diamminedichloroplatinum II, CDDP, cis DDP, DDP) is an inorganic platinum complex, which is able to inhibit DNA synthesis by … WebApr 14, 2024 · The investigations demonstrated different impacts of cisplatin on CTR1 expression on the single-cell level according to the resistance status. The study showed this interrelation for the first time at the single-cell level. It could be shown in this study that the resistant ovarian cancer cells as compared to the sensitive cells are ... WebWe recently reported that human and mouse cells containing an African-specific coding region variant of p53, Pro47Ser (hereafter S47), are impaired in the transactivation of a small subset of p53 ... canned nut meat

Granulocyte-colony stimulating factor does not prevent in vitro ...

Category:Targeted therapy for cisplatin‐resistant lung cancer via …

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Cisplatin mouse

Cisplatin-induced immune modulation in ovarian cancer mouse ... - PubMed

WebCisplatin for injection is a highly emetogenic antineoplastic agent; premedicate with anti-emetic agents; without antiemetic therapy, marked nausea and vomiting occur in almost … WebSep 1, 2024 · First, we examined whether cisplatin altered renal iron levels and induced oxidative stress in mice. Cisplatin increased the production of ferrous iron and hydroxyl radical, and they were colocalized in the kidney, suggesting the occurrence of the Fenton reaction ( Fig. 1 A–C).

Cisplatin mouse

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WebDec 2, 2024 · Cisplatin is a commonly used chemotherapeutic drug for cancer treatment, but its nephrotoxicity may lead to the deterioration of renal function. Previous work has been focused on cisplatin-induced acute … WebCisplatin-induced immune modulation in ovarian cancer mouse models with distinct inflammation profiles The backbone of ovarian cancer treatment is platinum-based chemotherapy and aggressive surgical debulking.

WebMay 11, 2012 · Mice were given LPs-pVAX or LPs-pVAX-LKB1 complexes by intratumoral injection at a dose of 20 μg per mice and/or low-dose cisplatin (2 mg kg −1 per mice) by i.p injection. After 24 h of the ... WebDec 24, 2024 · In this approach, cisplatin treatment was started when primary tumors were palpable (200–300 mm 3 ). When primary tumors bearing legs reached 15–17 mm (Day 35), three mice from control and...

WebWhile cisplatin was highly toxic—for example, causing kidney damage when used at a high dose—the mice were able to tolerate the drug in low doses. More importantly, the tumors responded to cisplatin and shrank. … WebAbstract Cisplatin (DDP) is a common therapeutic option for non-small cell lung carcinoma (NSCLC). However, some patients fail to respond to the DDP chemotherapy. ... Thus, …

WebMay 26, 1998 · Cisplatin is used to treat a wide variety of cancers in addition to testicular tumors (3, 4), although its effectiveness is often limited by its inherently poor activity against many tumor types and by the development of resistance . canned oatmealWebOct 1, 2024 · Cisplatin, the most widely used platinum-based anticancer drug, often causes progressive and irreversible sensorineural hearing loss in cancer patients. However, the precise mechanism underlying cisplatin-associated ototoxicity is still unclear. Nicotinamide adenine dinucleotide (NAD+), a … canned oat milkWebstudies in mice and rats, cisplatin acted as a tumor initiator follow-ing transplacental exposure via a single intraperitoneal injection late in gestation. In mice, transplacental … fix patchesWebMar 16, 2024 · Cisplatin is an alkylating-like platinum-based chemotherapeutic drug commonly used in paediatric oncology [ 5 ]. The understanding of how exposure to cisplatin affects the future fertility of pre-pubertal boys predominantly comes from retrospective follow-up studies [ 6 ]. canned nuts at costcoWebCisplatin is one of the most widely used chemotherapeutic drugs in the treatment of a wide range of pediatric and adult malignances. However, it has various side effects which limit its use.... fix path traversal vulnerability javaWebOur previous studies indicated that cisplatin administration to mice caused muscle atrophy. This is a concern for human patients receiving cisplatin. The insulin-like growth factor 1 (IGF-1)/phosphoinositide 3-kinase (PI3K)/Akt pathway stimulates the rate of protein synthesis in skeletal muscle. canned nutro dog foodWebFeb 18, 2024 · C57BL/6 mice were intraperitoneally injected with cisplatin (15 mg/kg) and then sacrificed at 8, 12, 24, and 72 h. A The body weight decreased 8–72 h after cisplatin treatment ( n = 4). B... canned oats