Cullin-ring ligase
WebCullin-4A is a protein that in humans is encoded by the CUL4A gene. [4] [5] CUL4A belongs to the cullin family of ubiquitin ligase proteins and is highly homologous to the CUL4B protein. CUL4A regulates numerous key processes such as DNA repair, chromatin remodeling, spermatogenesis, haematopoiesis and the mitotic cell cycle. WebCullin-RING ligase 5 (CRL5) is a multi-protein complex and consists of a scaffold protien cullin 5, a RING protein RBX2 (also known as ROC2 or SAG), adaptor …
Cullin-ring ligase
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WebAbstract. SCF Cdc4 (S kp1, C dc53/cullin, F-box protein) defines a family of modular ubiquitin ligases (E3s) that regulate diverse processes including cell cycle, immune … WebWe show that ABL kinases phosphorylate and interact with CUL4A, a cullin ring ligase adaptor, and compete with CPSF1 for CUL4A binding, leading to increased HIF-1α protein levels. Further, we identified the MYC proto-oncogene protein as a second CPSF1 substrate and show that active ABL kinase protects MYC from CPSF1-mediated degradation.
WebOct 22, 2014 · 4WQO. PubMed Abstract: The von Hippel-Lindau tumor suppressor protein (VHL) recruits a Cullin 2 (Cul2) E3 ubiquitin ligase to downregulate HIF-1α, an essential transcription factor for the hypoxia response. Mutations in VHL lead to VHL disease and renal cell carcinomas. Inhibition of this pathway to upregulate erythropoietin production is … WebCullin-RING ligases (CRLs) are the largest family of E3 ubiquitin ligases that promote the ubiquitination of about 20% of cellular proteins doomed for degradation through UPS . …
WebCullin-RING Ligase Regulation by the COP9 Signalosome: Structural Mechanisms and New Physiologic Players Feng Rao, Hong Lin, Yang Su Pages 47-60 Coordinated Actions Between p97 and Cullin-RING Ubiquitin Ligases for Protein Degradation Wenbo Shi, Ran Ding, Pei Pei Zhou, Yuan Fang, Ruixi Wan, Yilin Chen et al. Pages 61-78 WebCullin-RING ubiquitin ligases (CRLs) represent the largest superfamily of multi-subunit E3s conserved in all eukaryotes. Soon after the discovery of these important ubiquitin ligase machineries, structural studies have made tremendous contributions to our …
WebCullin-RING E3 ubiquitin ligases (CRLs) control a plethora of biological pathways through targeted ubiquitylation of signalling proteins. These modular assemblies use substrate receptor modules to recruit specific targets. Recent efforts have focused on understanding the mechanisms that control the …
WebAbstract Ubiquitin E3 ligases control every aspect of eukaryotic biology by promoting protein ubiquitination and degradation. At the end of a three-enzyme cascade, ubiquitin ligases mediate the transfer of ubiquitin from an E2 ubiquitin-conjugating enzyme to specific substrate proteins. littering clean upWebJun 10, 2016 · Cullin-RING ligases (CRLs), the largest E3 ubiquitin ligase family, promote ubiquitination and degradation of various cellular key regulators involved in a broad array of physiological and pathological processes, including cell cycle progression, signal transduction, transcription, cardiomyopathy, and tumorigenesis. littering costsWebFeb 18, 2024 · Cullin-RING E3 ubiquitin ligases (CRLs) direct protein degradation to impact a myriad of physiological and pathological processes including cancer. This work reports the small-molecule compounds 33-11 and KH-4-43 as inhibitors of E3 CRL4 with anticancer potential. These compounds have provided an opportunity for developing tool … littering complaintWebAug 28, 2013 · Modular CULLIN-RING ubiquitin ligases (CRLs) are the most prevalent class of E3s, comprising hundreds of distinct CRL complexes with the potential to recruit as many and even more protein substrates. littering cpcWebApr 7, 2024 · E3s can be classified in three main types, depending on the presence of characteristic domains: the homologous to E6-AP C-terminus (HECT), really interesting new gene (RING), and RING-between-RING (RBR) domains [ 8 ]. The RING-type ubiquitin ligase family represents the most abundant human E3s with over 600 members [ 9 ]. littering community serviceWebubiquitin ligases in humans, the Cullin-RING (Really Interesting New Gene) ligases (CRLs) (6, 7). Some 200 of these enzymes can be found in our cells and account for at least … littering costs moneyWebThe COP9 signalosome (CSN) is a signaling platform controlling the cellular ubiquitylation status. It determines the activity and remodeling of ~700 cullin-RING ubiquitin ligases … littering criminal offense definition