Peroxisome proliferator-activated receptor-伪
WebPrevious studies have hinted at a possible role for the transcription factor Peroxisome Proliferator-Activated Receptor alpha (PPARα) in cold-induced browning. Here we aimed … WebPeroxisome proliferator-activated receptor alpha (PPARα) is an important regulator of lipid metabolism. It has been suggested to affect both thrombosis and hemostasis, yet the …
Peroxisome proliferator-activated receptor-伪
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WebMar 29, 2024 · Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors, which consist of three subtypes, namely PPARα, β/δ and γ . They share considerable … WebMay 14, 2024 · Peroxisome proliferator-activated receptor a (PPARα, NR1C1) is a ligand-activated nuclear receptor involved in the regulation of lipid catabolism and energy homeostasis. PPARα activation induces he...
In the field of molecular biology, the peroxisome proliferator-activated receptors (PPARs) are a group of nuclear receptor proteins that function as transcription factors regulating the expression of genes. PPARs play essential roles in the regulation of cellular differentiation, development, and … See more Three types of PPARs have been identified: alpha, gamma, and delta (beta): • α (alpha) - expressed in liver, kidney, heart, muscle, adipose tissue, and others • β/δ (beta/delta) - expressed in many tissues, especially in See more All PPARs heterodimerize with the retinoid X receptor (RXR) and bind to specific regions on the DNA of target genes. These DNA sequences are termed PPREs (peroxisome proliferator hormone response elements). The DNA consensus sequence is … See more PPARα and PPARγ are the molecular targets of a number of marketed drugs. For instance the hypolipidemic fibrates activate PPARα. The anti diabetic thiazolidinediones activate PPARγ. The synthetic … See more • [1] (PPAR Resource Page, Penn State University). • [2] (Nuclear Receptor Resource). • PPAR reference outline Archived 2024-02-14 at the Wayback Machine (Rutgers … See more The three main forms of PPAR are transcribed from different genes: • PPARα - chromosome 22q12-13.1 (OMIM 170998) • PPARβ/δ - chromosome 6p21.2-21.1 (OMIM See more Like other nuclear receptors, PPARs are modular in structure and contain the following functional domains: • See more • Metabolic syndrome • Endocannabinoid system See more WebA transgenic 'knock-in' mouse model expressing a human UGT1 locus (Tg-UGT1) was recently developed and validated. Although these animals express mouse UGT1A pr
WebMar 21, 2024 · Peroxisome proliferator-activated receptors (PPARs) are essential nuclear hormone receptors regulating metabolic processes, and they participate in the initiation and progression processes of tumors. Gastrointestinal (GI) cancer is a prevalent malignancy worldwide that originates from the tissues of the gastrointestinal tract and is ... WebApr 12, 2024 · To investigate the molecular mechanisms underlying autophagy inducing pulmonary vascular remodeling and rosiglitazone inhibiting pulmonary arterial hypertension (PAH). Monocrotaline (MCT) was intraperitoneally injection to induce the rat PAH model. The right ventricular hypertrophy index (RVHI), right ventricle systolic pressure (RVSP), …
WebPeroxisome-proliferator activator receptors (PPARs) form a family of nuclear hormone-activated receptors and transcription factors that regulates the function and expression …
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