WebBioinformatic analysis and expression profile of human PHF23. The human PHF23 gene is located on chromosome 17p13.1 and contains 5 exons ().The full-length cDNA and predicted amino acid sequences are shown in Fig. S1A.The PHF23 gene is highly evolutionarily conserved (Fig. S1B).The PHF23 protein consists of 403 amino acid … WebNov 16, 2007 · Chromosomal translocations in a number of hematopoietic malignancies, including AML and MDS, result in the formation of NUP98 gene chimeras. Recently, fusion of NUP98 with a novel gene, PHF23 or plant homeodomain (PHD) finger 23, was reported in a cryptic translocation in a patient with AML (Reader et al., 2007). PHF23 is one of three …
(PDF) An Epigenetic Mechanism Underlying Chromosome …
WebPHF23 has originally been identified as an autophagy-related gene using an approach of functional genomics.20 To follow up, we designed a series of experiments to further explore the poten-tial relationship between PHF23 and autophagy. It was noted that PHF23 overexpression failed to affect the occurrence of WebJul 15, 2024 · The reduction of collagen II, a main component of cartilage matrix which is only secreted by chondrocytes, is a prominent feature of OA. Immunofluorescent staining of collagen II was performed on PHF23 knockdown and control chondrocytes treated with or without IL-1β. As shown in Fig. 2 (A), collagen II fluorescent signal was decreased both in … nys theatrical esd
PHF23 negatively regulates the autophagy of chondrocytes in ...
WebIn this report, we show that expression of a NUP98-PHF23 (NP23) fusion, associated with acute myeloid leukemia (AML) in humans, leads to myeloid, erythroid, T-cell, and B-cell leukemia in mice. The leukemic and pre-leukemic tissues display a stem cell-like expression signature including Hoxa, Hoxb, and Meis1 genes. The PHF23 PHD domain is known to … WebJul 15, 2024 · PHF23 is a new autophagy inhibitor which was first reported by us previously. This study aimed to explore the anti-autophagic mechanism of PHF23 to make it a possible therapeutic target of OA. Main method: Lentiviral vectors specific to PHF23 were used on chondrocytes (C28/I2) to establish PHF23 overexpressed or knockdown stable cell strains. WebThe PhotoKleen ™ NTD filter utilizes an all fluoropolymer construction for the ultimate compatibility and cleanliness. It also offers extremely low pressure drop. Features Easy change out style filter capsule Minimized hold-up volume, and top in / top out flow direction, with inlet flow stream down to the bottom nys theater institute