WebThiodiglycolic acid (TdGA) is the major metabolite of vinyl chloride monomer (VCM) detected in human urine. Although urinary TdGA has been reported to be associated with … WebApr 12, 2024 · Thiodiglycolic acid and t,t-muconic acid was purchased from Alfa Aesar (Massachusetts, United States). ... In the first step, 0.5 mL of urine sample spiked with 20 μL of internal standard, and 1 mL acidified methanol (using 0.1% formic acid pH 3) as an extraction solvent were added into the LLME extraction syringe setup, and extracted under …
Vinyl Chloride ToxFAQs™ ATSDR - Centers for Disease …
WebDec 28, 2004 · Abstract Thiodiglycolic acid (TDGA) is a product of interaction of the cysteine component of glutathione (GSH) with two‐carbon units released during catabolism. … WebSep 1, 2013 · A GC-MS method is described for the determination of thiodiglycolic acid in 1 ml-samples of urine. The variation coefficient for a series of four determinations was 2.7%. hsss meaning
Simultaneous biomonitoring of volatile organic ... - ScienceDirect
WebThe amount of the major breakdown product of vinyl chloride, thiodiglycolic acid, in the urine may give some information about exposure. However, this test must be done shortly … WebSep 1, 1979 · S-(carboxymethyl)-L-cysteine (CMC) and thiodiglycollic acid (TGA) were identified by gas chromatographic-mass spectrometric measurements in the urine of rats after intraperitoneal injections of 2,2′-bis-(chloroethyl)-ether (BCEE).It is therefore probable that BCEE is O-dealkylated by a mixed-function oxidation.The hepatocarcinogenic effect … WebOct 1, 2015 · The use of the “dilute-and-shoot” method helps to shorten the sample preparation stage and provides a sensitive and direct approach for TDGA determination in urine. A new sensitive rapid-separation liquid chromatography tandem mass spectrometry approach for the determination of thiodiglycolic acid (TDGA) in urine has been developed. … hss software technologies private limited